オフポンプ冠動脈バイパス手術中のヒトにおける左心室のシストリック機能
P M Brown1, V B Kim, B J Boyer
1Department of Surgery, Division of Cardiothoracic Surgery, East Carolina University School of Medicine, Greenville, NC 27858, USA.
Circulation
|November 24, 1999
まとめ
局所閉塞によるオフポンプ冠動脈バイパス移植 (CABG) は一時的な心筋不全を引き起こし,シストリック機能に影響します. しかし,再注射で機能が完全に回復し,永久的な損傷はないが,特定の患者グループにおいて臨床的意義がある可能性があることを示唆している.
科学分野:
- 心血管外科手術についてです.
- 心臓生理学 心臓生理学
- 心筋力衰弱症の研究について
背景:
- ローカル冠動脈閉塞を用いたオフポンプ冠動脈バイパス移植 (CABG) 中の心筋梗塞の臨床的重要性を調査する.
- 心臓外科手術患者における局所冠動脈閉塞の地域静脈機能への影響を評価する.
研究 の 目的:
- オフポンプCABG中に局所的な冠動脈閉塞が局所的な静脈機能に及ぼす影響を判断する.
- CABGの手続きの文脈で局所閉塞後の心筋梗塞の程度と回復を評価する.
主な方法:
- CABGを受けていた8人の患者で,圧力カテーテルと超音波寸法トランスデューサを使用した.
- 測定された地域性シストリック機能 (シストリック縮小率) と,左前下流動脈の局所的閉塞前,中,および後の圧力-次元ループ.
- 冠動脈狭窄の度合いとセグメンタル縮小の変化の相関を分析した.
主要な成果:
- 局所的な冠動脈閉塞は,ピークシストリック縮小の有意な減少につながりました (5.8%から1.8%).
- 心筋機能は,血流が回復した後,完全でベースラインレベルに回復し,下痢性クリープの証拠はありません.
- 冠動脈狭窄の程度とセグメンタル短縮の減少の間に有意な逆相関が観察されました.
結論:
- CABG中の一時的な局所性冠動脈閉塞は,一時的な心筋機能不全を引き起こすが,永久的な損傷は引き起こさない.
- 完全機能回復は再注射時に起こり,イシュケミアの一時的な性質を示します.
- これらの缺血性変化の臨床的意義は,より軽度の冠動脈狭窄症の患者でより大きいかもしれません.
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