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Updated: Jul 15, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

酸化ストレスは,イカッパ・バルファの劣化なしにNF-kappaB核転位を誘導する

T G Canty1, E M Boyle, A Farr

  • 1Department of Surgery, University of Washington, Seattle 98104-2924, USA.

Circulation
|November 24, 1999
PubMed
まとめ

酸化ストレスは,新しい経路を通じて心臓細胞の核因子-kappaB (NF-kappaB) を活性化します. このメカニズムは,通常のイカッパバルファの分解を回避し,イシュケミア-再流出損傷中のNF-kappaBシグナル伝達においてチロシンリン酸化が明確な役割を果たすことを示唆しています.

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