漸進的な超核性麻痺と多重系縮の流行:横断的な研究
A Schrag1, Y Ben-Shlomo, N P Quinn
1Department of Clinical Neurology, Institute of Neurology, London, UK.
Lancet (London, England)
|November 30, 1999
まとめ
進行性超核性麻痺 (PSP) と多発性システム縮 (MSA) の流行率は,これまで考えられていたよりも高い. これらのパーキンソン病障害を持つ多くの個人は,コミュニティで診断されず,または誤って診断されています.
科学分野:
- 神経学 神経学とは
- エピデミオロジー エピデミオロジー
背景:
- 進行性超核性麻痺 (PSP) と多発性システム縮 (MSA) の集団の罹患率はほとんど不明です.
- 研究によると,これらのパーキンソン病疾患は,一般人では診断が不十分である可能性が高い.
研究 の 目的:
- PSPとMSAの流行を調査する.
- これらの疾患の診断が不十分であるかどうかを判断する.
主な方法:
- パーキンソン病に関連する診断と抗パーキンソン病薬の使用について,ロンドンの15の一般診療所のコンピュータ化された記録をスクリーニングしました.
- 診断の確認のために記録のレビュー,インタビュー,身体検査,ビデオ分析を通じて適格な患者を評価しました.
- パーキンソン病の診断基準を公表し,非典型症例の追跡期間は1年.
主要な成果:
- 年齢調整されたPSPの罹患率は10万人に6.4人,MSAの罹患率は10万人に4.4人でした.
- PSPとMSAを組み合わせた合計11の確率または可能性のある症例を特定しました.
- さらに4つの非典型症例が特定されたが,フォローアップ時にPSPまたはMSAの基準を満たさなかった.
結論:
- PSPとMSAの真の罹患率は,一般集団で過小評価されている可能性が高い.
- これらの神経疾患を患っている患者の有意な数は,コミュニティで診断されていないか,誤診されているままです.
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