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Updated: Jul 31, 2026

Osteoclast Derivation from Mouse Bone Marrow
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Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

アクティベーションされたT細胞は,オステオプロテゲリンのリガンドを通じて,補助性関節炎における骨の喪失と関節破壊を調節する

Y Y Kong1, U Feige, I Sarosi

  • 1Amgen Institute, Toronto, Ontario, Canada.

Nature
|December 2, 1999
PubMed
まとめ

活性化されたT細胞は,オステオプロテゲリン・リガンド (OPGL) を通して,直接的にオステオクラステオゲネシスと骨喪失を誘発する. OPGLを阻害すると,関節炎で骨の破壊が防止され,T細胞が骨の生理学の重要な調節体であることを明らかにします.

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