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Updated: Jul 6, 2026

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
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Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

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p66shcアダプタータンパク質は,哺乳類の酸化ストレス反応と寿命を制御する

E Migliaccio1, M Giorgio, S Mele

  • 1Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

Nature
|December 2, 1999
PubMed
まとめ

マウスのp66shc遺伝子をターゲットにすることで,ストレスに対する細胞の抵抗性を高め,寿命を大幅に延長します. この発見は,哺乳類のストレス反応機構と老化過程に光を当てています.

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