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Updated: Jul 13, 2026

Reconstitution of Nucleosomes with Differentially Isotope-labeled Sister Histones
09:26

Reconstitution of Nucleosomes with Differentially Isotope-labeled Sister Histones

Published on: March 26, 2017

翻訳後の品質管理: タンパク質の折りたたみ,再折りたたみ,分解

S Wickner1, M R Maurizi, S Gottesman

  • 1Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892-4255, USA.

Science (New York, N.Y.)
|December 3, 1999
PubMed
まとめ

タンパク質の折り畳み品質管理は,分子チャペロンとプロテアゼに依存しています. これらのシステムのバランスがタンパク質の運命を決定し,アグリゲーションとアミロイド疾患を予防します.

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Protein Folding

Overview
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Proteins: From Genes to Degradation

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Protein Folding

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Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
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