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Updated: Jul 7, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

ペプチドとMHCクラスIIの複合体内のT細胞受容体の結晶構造

E L Reinherz1, K Tan, L Tang

  • 1Laboratory of Immunobiology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 3, 1999
PubMed
まとめ

結晶構造は,T細胞受容体 (TCRs) がMHCクラスII分子によって提示される外来ペプチド抗原に結合する方法を明らかにします. ペプチド拡張によって誘発されるこの直角結合モードは,TCR認識に影響を与え,免疫応答の洞察を提供します.

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