中耳炎の遺伝性:双子と三重子の研究
M L Casselbrant1, E M Mandel, P A Fall
1Department of Otolaryngology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, PA 15213, USA. casselm@chplink.chp.edu
JAMA
|December 11, 1999
まとめ
遺伝子は子どもにおいて重要な役割を果たします.
科学分野:
- 小児 otorhinolaryngology (小児 otorhinolaryngology) とは,小児 otorhinolaryngology (小児 otorhinolaryngology) とは,小児 otorhinolaryngology (小児 otorhinolaryngology) とは,小児 otorhinolaryngology (小児 otorhinolaryngology) とは,小児 otorhinolaryngology (小児 otorhinolaryngology) とは,小児 otorhinolaryngology (小児 otorhinolaryngology) とは,小児 otorhinolaryngology (小児 otorhinolaryngology) とは,小児 otorhinolaryngology (小児 otorhinolaryngology) とは
- 感染症の遺伝学
- 幼児期の病気の流行病学
背景:
- 既存のデータは,子供における長期および再発性中耳炎に遺伝的影響があることを示唆しています.
- 中耳炎,特に急性中耳炎 (AOM) は,潜在的に長期的な結果をもたらす一般的な子供の病気です.
研究 の 目的:
- 生後2年目の中耳漏れおよびAOMに対する遺伝的寄与を定量化するために.
- 中耳出血およびAOMエピソードの持続時間および頻度の遺伝性を調査する.
主な方法:
- 1982年から1995年にかけて,双子と三胞胎を対象とした前向きなコホート研究が行われました.
- 168人の同性双子と7人の三人組を募集し,最大2年間追跡調査を行った.
- 分析は,中耳の出血による時間の割合,出血およびAOMエピソードの数,ジゴス性によって層分化に焦点を当てた.
主要な成果:
- 中耳出血による時間に対する遺伝性は,2年後に0.73 (P<.001) と推定された.
- 一卵性双生児は,二卵性双生児と比較して,複数の中耳出血エピソード (0.04) とAOMエピソード (0.04) の不協和率を著しく低下させた (それぞれ0.37と0.49).
- 不一致の差のP値は,噴出エピソードではP = .01,AOMエピソードではP = .005でした.
結論:
- この研究は,子どもにおける中耳出血およびAOMの持続時間および頻度に影響を与える重要な遺伝的要素の有力な証拠を提供します.
- これらの発見は,中耳炎の感受性および進行における遺伝因子の重要性を強調しています.
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