肥満や肥満の成人のC反応性タンパク質濃度の上昇
M Visser1, L M Bouter, G M McQuillan
1Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands. m.visser.emgo@med.vu.nl
JAMA
|December 11, 1999
まとめ
体重過多と肥満は,低度の全身性炎症と関連しており,C反応性タンパク質 (CRP) レベルが上昇していることが示されています. この関連性は,若い成人でも持続し,重大な健康上の懸念を浮き彫りにしています.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 免疫学 免疫学とは
- 公衆衛生は公衆衛生である.
背景:
- 脂肪組織は,炎症を誘発するサイトカインであるインタールイキン-6を放出します.
- 過剰な体脂肪は,低度の全身性炎症を引き起こす可能性があります.
研究 の 目的:
- 体重過多/肥満と全身性炎症の関連性を調査する.
- 血清のC反応性タンパク質 (CRP) レベルを使用して全身の炎症を測定する.
主な方法:
- 第3回全国保健栄養調査 (1988-1994) のデータを活用した.
- 17歳以上の男性16,616人,妊娠していない女性16,616人を含む.
- 定義されたCRP上昇は≥0.22 mg/dLであり,臨床的にCRP上昇は>1.00 mg/dLである.
主要な成果:
- 人口の27.6%と6.7%は,それぞれCRPが上昇し,臨床的に上昇していた.
- 体重過多および肥満の個人は,正常体重の個人に比べて,CRPが上昇する可能性が高いことを示しました.
- 肥満の男性 (OR 2.13) と女性 (OR 6.21) は,調整後のCRP上昇の確率が著しく高かった. 肥満の女性はまた,臨床的に上昇したCRP (OR 4.76) の確率も高かった.
- 腰から腰までの比率は,BMIから独立してCRPレベルと正に相関していました.
結論:
- 体重指数 (BMI) の上昇は,CRP濃度の上昇と相関しています.
- 発見は,過体重および肥満の個体において,低度の全身性炎症の状態を示しています.
- BMIと炎症の関連性は,若い成人 (17-39歳) にさえも明らかである.
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