自然抗体による早期のウイルスおよび細菌の分布と病気の制御
A F Ochsenbein1, T Fehr, C Lutz
1Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.
Science (New York, N.Y.)
|December 11, 1999
まとめ
天然の抗体は,感染症と戦うために不可欠です. これらの抗体が欠けているマウスでは,病原体がより容易に重要な臓器に広がり,その保護的役割を強調します.
科学分野:
- 免疫学 免疫学とは
- 感染症 感染症とは
背景:
- 自然抗体は,免疫学的研究においてしばしば無視される.
- しかし,それらは病原体に対する宿主防御に有意に寄与する可能性があります.
研究 の 目的:
- ウイルスおよび細菌感染症に対する免疫における天然抗体の役割を調査する.
- 病原体の拡散と免疫反応に対する自然抗体の影響を決定する.
主な方法:
- ウイルスまたはListeria monocytogenesの感染後に抗体フリーマウスと抗体適合マウスの病原体タイターの比較.
- 周辺臓器 (腎臓,脳) と二次リンパ性臓器における病原体のレベルを分析する.
主要な成果:
- 抗体のないマウスは,抗体に適したマウスと比較して,外周臓器における病原体タイターが10~100倍高いことを示した.
- 抗体のないマウスの二次リンパ性臓器では,病原体の位数が10~100倍低かった.
- 抗体のないマウスは,特定の感染症に対する感受性の上昇を示した.
結論:
- 自然な抗体は,病原体が重要な臓器に広がるのを防ぐために不可欠です.
- 彼らは,二次リンパ性臓器における抗原のトラッピングを促進することによって,免疫原性を高めます.
- 自然の抗体は,感染症に対する免疫を与える上で重要な役割を果たします.
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