関連する実験動画
Updated: Jul 14, 2026
13:01
Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development
Published on: April 10, 2016
Tbx5と網膜内膜のプロジェクション
K Koshiba-Takeuchi1, J K Takeuchi, K Matsumoto
1Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, Japan 630-0101.
Science (New York, N.Y.)
|December 30, 1999
まとめ
Tbx5遺伝子は目の発達に影響を与え,視覚投影を導く. Tbx5を誤って表現すると,目の形状と網膜軸索経路が変化し,目の形態変異と地形図の描写におけるその役割が明らかになった.
科学分野:
- 発達生物学 発達生物学とは
- 神経科学は神経科学である.
- オフタルモロジック (眼科)
背景:
- 眼球は,初期の段階から,明確な背中と内部の発達を示しています.
- 胸腔裂けは,眼球が背面に成長するにつれて腹部に形成されます.
- 網膜軸索は,トポグラフィックプロジェクションをテクトムに表示します (背網膜から腹網膜,腹網膜から背網膜).
研究 の 目的:
- 眼の形態発生におけるTbx5遺伝子の役割を調査する.
- Tbx5が網膜軸索のトポグラフィックマッピングをテクタムに影響するかどうかを判断する.
主な方法:
- 目の発達と網膜軸突のプロジェクションの分析.
- 発達中の目のTbx5遺伝子の遺伝的誤発現.
主要な成果:
- Tbx5の誤った発現は,眼内側側がドルサライゼーションに繋がった.
- Tbx5誤発現の後に,網膜のギャングリアン細胞軸索の変化した投影が観察されました.
結論:
- Tbx5は,目の形態変異に重要な役割を果たしています.
- Tbx5は,網膜とテクトムとの間の視覚投影のための地形学的な決定因子として作用します.
関連する概念動画
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...