関連する実験動画

Updated: Jul 16, 2026

Chromosome Preparation From Cultured Cells
07:42

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

Li-Fraumeni症候群におけるヘテロジゴトの生殖線hCHK2変異は,Li-Fraumeni症候群において発生する

D W Bell1, J M Varley, T E Szydlo

  • 1Massachusetts General Hospital Center for Cancer Risk Analysis and Harvard Medical School, Building 149, Charlestown, MA 02129, USA.

Science (New York, N.Y.)
|January 5, 2000
PubMed
まとめ

ヒトのチェックポイントキナーゼ2 (hCHK2) 遺伝子の変異は,遺伝的な癌性傾向であるLi-Fraumeni症候群と関連しています. これは,hCHK2が腫瘍抑制剤として作用し,肉腫,乳がん,脳がんのリスクに影響を及ぼすことを示唆しています.

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