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Updated: May 4, 2026

Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa
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Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa

Published on: June 30, 2016

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バクテリアの信号伝導における一時的にリン酸化されたスイッチの構造

D Kern1, B F Volkman, P Luginbühl

  • 1Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, USA. dkern@brandeis.edu

Nature
|January 6, 2000
PubMed
まとめ

この研究は,細菌のシグナル伝達タンパク質の受容体領域の活性構造を明らかにしています. リン酸化は形状の変化を引き起こし,細菌の増強剤結合タンパク質NtrCの信号伝送に不可欠な表面を露出させます.

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