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Updated: Jul 20, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

ガンマデルタT細胞受容体リガンドT22の結晶構造:切断されたMHCのような折りたたみ

C Wingren1, M P Crowley, M Degano

  • 1Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|January 15, 2000
PubMed
まとめ

ネズミのT10とT22,関連する非古典的なMHC Ibタンパク質は,ガンマデルタT細胞受容体に直接結合する. 構造分析は,異常なMHCのような折り目を明らかにし,異なるガンマデルタとアルファベータT細胞受容体相互作用を示唆しています.

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