手首骨折における反射交感性ジストロフィーの頻度に対するビタミンCの効果:ランダム化試験
P E Zollinger1, W E Tuinebreijer, R W Kreis
1Department of Orthopaedics, Leyenburg Hospital, The Hague, The Netherlands.
Lancet (London, England)
|January 15, 2000
まとめ
ビタミンCのサプリメントは,手首骨折後の反射交感性ジストロフィー (RSD) のリスクを有意に低下させました. この抗酸化物質は,類似の傷害において,外傷後のジストロフィーを予防するのに役立ちます.
科学分野:
- 整形外科の手術は,整形外科の手術です.
- トラウマトロジーはトラウマトロジーの治療法です.
- 臨床薬理学 臨床薬理学とは
背景:
- 反射交感性ジストロフィー (RSD) の病原性と治療法は不明である.
- トラウマ後ジストロフィーに関連した高い罹病率,医療費,労働欠席は,予防戦略を必要とします.
- 有毒な酸素ラジカルの潜在的な役割のために,予防的な抗酸化剤としてビタミンC (アスコルビック酸) を調査した.
研究 の 目的:
- 保守的に治療された手首骨折後の,外傷後の反射交感性縮症 (RSD) に対する予防薬としてビタミンCの有効性を評価する.
主な方法:
- 展望型,ダブルブラインド,ランダム化試験で,手首の骨折が127件で123人の成人を対象とした.
- 参加者は50日間,毎日500mgのビタミンCまたはプラセボを投与されました.
- RSDの臨床スコアとフォローアップは1年以上にわたって行われました.
主要な成果:
- RSDは,ビタミンC群の腕の7%で,プラセボ群の22%に対して発生しました (15%の違い).
- ビタミンCのサプリメント摂取は,RSDを発症するリスクが著しく低下するとの関連がありました.
- 鋳造と骨折のタイプの苦情は,RSDの発生のための重要な予後変数でもありました.
結論:
- ビタミンCの予防は,手首骨折後の反射交感性ジストロフィーのリスクの低下と関連していました.
- この発見は,トラウマ後ジストロフィーの予防にビタミンCが潜在的に有益な役割を果たす可能性を示唆しています.
- この予防効果は,他の形態のトラウマにも及ぶ可能性があります.
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