低用量経口避妊薬と活性化タンパク質Cに対する獲得抵抗:ランダム化クロスオーバー研究
J Rosing1, S Middeldorp, J Curvers
1Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Netherlands. j.rosing@bioch.unimaas.nl
Lancet (London, England)
|January 15, 2000
まとめ
第三世代の避妊薬,特にデソゲストレルを含む避妊薬は,第2世代の避妊薬よりも活性化タンパク質C (APC) に対する耐性を著しく増加させる. この獲得したAPC抵抗は,使用者の血栓のリスク増加に寄与する可能性があります.
科学分野:
- 薬理学 薬理学とは
- 血液学 ヘマトロジ
- 生殖器保健は,生殖器の健康についてです.
背景:
- 以前の研究では,第3世代の経口避妊薬 (OCs) が,第2世代のOCsと比較して活性化タンパク質C (APC) に対する耐性を高めることが示唆されていました.
- 横断的な設計は,潜在的なバイアスと制御されていない月経周期効果のために,以前の発見を制限しました.
研究 の 目的:
- 2代目と3代目のOCとAPC耐性との関連を調査する.
- 過去の研究のバイアスを克服するために,サイクル制御されたランダム化クロスオーバー試験を使用します.
主な方法:
- ランダム化クロスオーバー試験で,第2世代 (レボノルゲストレル) または第3世代 (デゾゲストレル) のOCをそれぞれ2サイクル使用した33人の女性を対象とした.
- 血のAPC感受性比を測定し,APCがトロンビン生成に及ぼす影響を評価した.
- OC製剤とプーリングされた対照プラズマを比較した.
主要な成果:
- 28人の女性が研究を完了しました.
- 両方のOCタイプは,正常化されたAPC感度比を増加させた.
- デゾゲストレルを投与した第3世代のOCは,レボノルゲストレルを投与した第2世代のOCと比較して,APC抵抗性の有意な増加を示した (p<0.0001).
結論:
- 経口避妊薬の使用は,APCの血栓形成のダウンレギュレーションにおけるAPCの有効性を低下させ,この現象は獲得APC耐性と呼ばれています.
- この獲得したAPC抵抗性は,レボノルゲストレルを含むOCよりもデソゲストレルを含むOCで顕著です.
- 静脈血栓塞栓症のリスクとの関係におけるOC誘発の獲得APC耐性の臨床的意義については,さらなる調査が必要である.
キーワード:
生物学 生物学 生物学とは血液タンパク質 血液タンパク質比較研究とは比較研究です.避妊は避妊手段として使います.避妊薬,女性 - 副作用避妊薬,プロゲスティン - 副作用避妊薬 - 副作用について避妊方法 避妊方法 避妊方法デソゲストレル - 副作用先進国 開発途上国ヨーロッパはヨーロッパです.ファミリープランニング 家族計画ヘミック・システム ヘミック・システムレボノルゲストレル - 副作用オランダ オランダ オランダ オランダ口服避妊薬は,口服避妊薬として使われています.口服避妊薬,低用量 避妊薬生理学 生理学とは研究方法論 研究方法論研究報告書 研究報告書勉強 勉強 勉強 勉強 勉強西ヨーロッパ 西ヨーロッパ 西ヨーロッパ関連する概念動画
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