ヴェラパミルの長期の心拍動脈誘発性心房電気再構築に対する効果
1Shin Kong Wu Ho-Su Memorial Hospital, National Yang-Ming University, Taiwan, ROC.
Circulation
|January 19, 2000
まとめ
ヴェラパミルは,犬の心拍不全から長期にわたる電気再構築を防ぐことはできませんでした. この薬は,ペースアップ前と後の両方で,心房細動 (AF) の持続時間を増加させました.
科学分野:
- 心血管電気生理学 心血管電気生理学
- 薬理学 薬理学とは
背景:
- バラパミルの長期間効果は,心拍不全によって誘発された心房の電気的改造にはまだ研究されていない.
- 心房リモデリングは,心房細動 (AF) の病理生理学における重要な要因です.
研究 の 目的:
- 犬のモデルで,急速な心房ペースの進行中および後の心房電気生理学的特性に対するヴェラパミルの影響を調査する.
- ベラパミルが心拍不全によって誘発される心房の電気的改造を予防または軽減できるかどうかを判断する.
主な方法:
- 48匹の犬はランダムにベラパミルと対照群に分けられた.
- アトリアル有効耐火期 (AERP),AF誘導性,AF持続時間は,1日,1週間,または6週間の急速な心房ペースの前後に評価されました.
- ヴェラパミルは,ヴェラパミル群に1日120mgで投与されました.
主要な成果:
- ヴェラパミルは1日間のペースアップ後にAERPの縮小,分散,不適応,AF誘導性を弱めた.
- これらの保護効果は,1週間のペースまたは6週間のペースの後には観察されなかった.
- ヴェラパミルは,ペースアップの前にAFの持続時間を大幅に延長し,1週間のペースアップと6週間のペースアップ後にそれを増加させた.
結論:
- ベラパミルは,長期間続く心拍不全によって引き起こされる心房の電気生理学的変化を予防しません.
- ヴェラパミルは,持続的な急激な心房ペースの文脈でAFの持続時間を悪化させる.
- これらの発見は,心房細動を有するまたは心房細動のリスクのある患者でヴェラパミルを使用する際の注意を示唆しています.
さらに関連する動画
06:57Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
Published on: January 31, 2019
16.6K
08:56Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
2.5K
関連する概念動画
01:28Mechanism of Cardiac Arrhythmias
2.7K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.7K
01:20Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
2.8K
Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
2.8K
01:30Cardiac Action Potential
11.8K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
11.8K
01:29Dysrhythmias III: Characteristics of Dysrhythmias
709
Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...
709
01:25Dysrhythmias VI: Management of Dysrhythmias
597
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
597
01:25ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
1.2K
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
1.2K