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Updated: Jul 5, 2026

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Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
アデノシン5'-トリフォスファートの静脈内および冠内投与の効果は,冠動脈の流れと圧力動態に対するアデノシンと比較して,アデノシン5'-トリフォスファートの効果です
A Jeremias1, S D Filardo, R J Whitbourn
1Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Circulation
|January 25, 2000
まとめ
アデノシン三リン酸 (ATP) は,冠動脈流量準備 (CFR) と断片流量準備 (FFR) を通して冠動脈狭窄を評価するためにアデノシンに相当します. しかし,両薬とも完全冠動脈閉塞と比較して最大高血圧を誘発しません.
科学分野:
- 心血管の生理学 心血管の生理学
- 介入性心臓病学 介入性心臓病学について
- 薬理学 薬理学とは
背景:
- 冠動脈流量準備量 (CFR) と断片流量準備量 (FFR) の測定は,最大高血圧を必要とする.
- アデノシンは標準的な高血圧誘発剤ですが,コストや耐受性などの欠点があります.
研究 の 目的:
- アデノシン・トリフォスファート (ATP) を,高血症を誘発するアデノシンの代替品として評価する.
- CFRとFFRの測定におけるATPとアデノシンの有効性を比較する.
主な方法:
- 犬とヒトの狭窄症におけるATPとアデノシンの等価性試験.
- 冠動脈内ATP,アデノシン,冠動脈閉塞を用いたCFRとFFRの測定.
- 両剤の投与量反応の評価.
主要な成果:
- ATPとアデノシンの両方がCFRとFFRを著しく増加させ,より高い用量はより大きな高血圧を生じさせた.
- ATPとアデノシンは,CFR (R=0.934) とFFR (R=0.985) の優れた線形相関を示した.
- ATPとアデノシンに対する高血圧反応は,冠動脈閉塞によって達成されたよりも少ない.
結論:
- ATPとアデノシンの投与量の増加は,標準的な臨床勧告を超えて冠動脈高血症を高めます.
- ATPは,CFRとFFRの評価のためにアデノシンに治療的に相当します.
- 薬理学的薬剤のいずれも最大度の高血圧を達成しなかったが,冠動脈閉塞はより優れた高血圧反応をもたらした.
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