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Updated: May 8, 2026

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
15:28

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells

Published on: October 2, 2010

KCNQ1とKCNE3によって形成される構成的に開いたカリウムチャンネル

B C Schroeder1, S Waldegger, S Fehr

  • 1Zentrum für Molekulare Neurobiologie Hamburg, Hamburg University, Germany.

Nature
|January 26, 2000
PubMed
まとめ

新型βサブユニットKCNE3はKCNQ1のカリウムチャネルを変化させ,急速な電流を生み出します. このKCNQ1/KCNE3チャネルは,腸内塩化物分泌に決定的な役割を果たし,システィック線維症などの疾患に影響を与える可能性があります.

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Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
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Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

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