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Updated: Jun 28, 2026

Murine Model of CD40-activation of B cells
12:24

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Published on: March 6, 2010

Cbl-bは,T細胞活性化のCD28依存を調節する

Y J Chiang1, H K Kole, K Brown

  • 1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.

Nature
|January 26, 2000
PubMed
まとめ

アダプター分子Cbl-bはT細胞の活性化を調節するので,Cbl-bが欠けているT細胞は,インタールイキン-2の産生のためにCD28の共刺激を必要としない. Cbl-b欠乏症は抗体反応を回復し,VaVの活性化を高め,自己免疫疾患の感受性に影響を与える.

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