麻疹の病歴とアトピー病:人口ベースの横断的研究
M Paunio1, O P Heinonen, M Virtanen
1Department of Public Health, University of Helsinki, Finland. mikko.paunio@stm.vn.fi
JAMA
|January 27, 2000
まとめ
天然麻疹の感染は,湿疹,鼻炎,喘息などのアトピー性疾患のリスクが高いことと関連しています. この研究では,麻疹がこれらの状態から保護するという証拠は見つかりませんでした.
科学分野:
- 免疫学 免疫学とは
- エピデミオロジー エピデミオロジー
- 公衆衛生は公衆衛生である.
背景:
- 横断的な研究は,麻疹を含む伝染病への曝露の減少が,裕福な国におけるアトピー病率の増加と相関することを示唆しています.
- 衛生仮説は,病原体への早期の曝露がアレルギー状態から保護することを提案しています.
研究 の 目的:
- 天然麻疹感染とアトピー病の流行の関連性を調査する.
- 天然麻疹の感染がアトピーに対する保護を提供するかどうかを判断する.
主な方法:
- フィンランド (1982年−1986年) で実施された全国の横断研究で,14ヶ月から19歳の54万7910人のデータを分析した.
- 麻疹の発生およびアトピー症状 (湿疹,鼻炎,喘息) に関するデータは,麻疹・疹・赤血球 (MMR) ワクチン接種時に収集されました.
- 流行比率は,麻疹の既往歴と既往歴のない人のアトピー率を比較するために計算されました.
主要な成果:
- 麻疹の病歴のある個人は,アトピー性疾患の年齢調整された有病率を大幅に高めた.
- 流行比率は,エクゼマでは1.32,鼻炎では1.41,喘息では1.67であった.
- この関連性は,すべての年齢,都市/農村環境,そしてさまざまなレベルの社会的接触において一貫していました.
結論:
- この発見は,麻疹の感染とアトピーとの間の肯定的な関連性を示している.
- この結果は,天然の麻疹感染が,アトピー病に対する保護を提供するという仮説を支持しません.
- 麻疹とアトピアは,予想以上に頻繁に同時発生しているようです.
さらに関連する動画
06:47Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
関連する概念動画
Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Introduction to Epidemiology
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
