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関連する概念動画

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...

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関連する実験動画

Updated: May 7, 2026

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
12:17

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay

Published on: January 19, 2012

脊椎動物の発達におけるノダルシグナル伝達

A F Schier1, M M Shen

  • 1Department of Cell Biology, New York University School of Medicine, New York 10016, USA. schier@saturn.med.nyu.edu

Nature
|February 10, 2000
PubMed
まとめ
この要約は機械生成です。

Nodalシグナル伝達経路経由の細胞通信は,初期の胚形成の間に脊椎動物の体プランを確立するために不可欠です. この経路は,軸形成と組織パターニングを含む主要な発達イベントを調節します.

さらに関連する動画

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
05:36

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

Published on: February 28, 2014

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

関連する実験動画

Last Updated: May 7, 2026

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
12:17

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay

Published on: January 19, 2012

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
05:36

Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development

Published on: February 28, 2014

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

科学分野:

  • 発達生物学 発達生物学とは
  • 細胞シグナリング
  • 分子生物学は分子生物学である.

背景:

  • 細胞のコミュニケーションは,脊椎動物の胚形成と身体計画組織にとって根本的なものです.
  • 変形成長因子βの超家族の一員であるノダル信号伝達経路は,胚の発達において中心的な役割を果たします.

研究 の 目的:

  • 脊椎動物の胚形成におけるノダル信号伝達経路の役割を明らかにする.
  • ノダルシグナリングがメソデームとエンドデームの形成,軸の仕様,神経パターンの形成をどのように調節するかを理解する.

主な方法:

  • ノダル信号伝達経路とその調節器を調査した.
  • EGF-CFCコファクターとLefty/Cerberusアンタゴニストによる細胞外調節に焦点を当てました.

主要な成果:

  • 節点信号は,脊椎動物の胚の構成に不可欠である.
  • 細胞外調節体は,ノダルの活動を正確に制御する.
  • ノダル経路の活動は,メソデルマ/エンドデルマ形成,前後軸,神経パターニング,左右軸の仕様に影響を与える.

結論:

  • ノダル信号伝達経路は,脊椎動物の早期発達の重要な調節器である.
  • 特定のタンパク質ファミリーによる Nodal 活動の細胞外調節は,精密な胚のパターニングを保証します.