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Analysis of Side Population in Solid Tumor Cell Lines
Published on: February 23, 2021
ダウン症候群患者の白血病および固体腫瘍のリスク
H Hasle1, I H Clemmensen, M Mikkelsen
1Department of Paediatrics, Aarhus University Hospital Skejby, Denmark. hasle@post2.tele.dk
Lancet (London, England)
|February 16, 2000
まとめ
ダウン症候群の個人は,小児白血病のリスクがかなり高く,固体腫瘍のリスクは低くなります. ダウン症候群におけるこのユニークな癌のパターンは,癌の発症に影響を与える遺伝的要因の洞察を提供します.
科学分野:
- 腫瘍学 腫瘍学
- 遺伝学 遺伝学とは
- 小児科は小児科です.
背景:
- ダウン症候群の個人は,一般の人々と比較して白血病のリスクが高くなります.
- この年齢層における特定年齢の白血病リスクと固形腫瘍リスクに関するデータは限られている.
研究 の 目的:
- ダウン症候群の個体における様々な癌の年齢特有のリスクを推定する.
- この集団における白血病と固体腫瘍の両方のパターンを調査するために.
主な方法:
- デンマーク・サイトジェネティック・レジスタとデンマーク・がん・レジスタのデータを利用し,ダウン症候群の2814人を対象とした.
- 一般人口の割合に基づいて計算された標準化発生率 (SIR) と95%信頼区間 (CI).
- 異なる年齢層と癌の種類におけるがん発生率を分析した.
主要な成果:
- 全体的ながん発生率は,特に小児の白血病リスクが高いことによって,わずかに上昇した (SIR 1.20),特に子供 (SIR 56 0-4歳).
- 30歳までに白血病の累積リスクは2.7%で,小児の急性骨髄性白血病は急性リンパ性白血病よりも頻繁に発生する.
- 固体腫瘍のリスクが著しく低下した (SIR 0.50) 乳がんの症例は見つかりませんでした.
結論:
- ダウン症候群における癌の発生は,子供の白血病のリスクが高く,固体腫瘍のリスクが低下するというユニークなプロファイルを示しています.
- ダウン症候群の癌の特徴的なパターンは,染色体21の白血病原性および腫瘍抑制遺伝子を特定するために貴重な手がかりを提供することができます.
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