ハーブ・ドラッグの相互作用
1George Washington University School of Medicine and Health Sciences, Department of Health Care Sciences, Washington, DC 20037, USA. fughberman@aol.com
Lancet (London, England)
|February 16, 2000
まとめ
薬草と医薬品を同時に使用すると,危険な相互作用が生じることがあります. 医療従事者は,潜在的な副作用のために,薬草と薬物の混合を避けるように患者に助言する必要があります.
科学分野:
- 薬理学 薬理学とは
- 統合医療とは一体化医療です.
- 薬草薬は,薬草薬として用いられる.
背景:
- 薬草製品と医薬品の同時使用は一般的です.
- 薬草は,薬剤と相互作用し,薬剤の有効性と安全性を変化させることがあります.
- これらのハーブ・ドラッグの相互作用を理解することは,患者のケアにとって極めて重要です.
研究 の 目的:
- ハーブ・ドラッグの相互作用に関する文書化された症例をレビューし,要約する.
- 薬草と医薬品を組み合わせることで生じる潜在的な有害効果を強調する.
- ハーブ薬の使用に関する臨床的意識と患者カウンセリングの重要性を強調する.
主な方法:
- 報告されたハーブ・ドラッグの相互作用に関する文献レビュー.
- 特定のハーブとその相互作用する薬剤の識別.
- 臨床的結果に基づく相互作用の分類 (例えば,出血,セロトニン症候群,生物学的利用性の変化).
主要な成果:
- ウォルファリンとジンコ,ニンニク,ドンクワイ,ダンシェンの併用は出血のリスクを高める可能性があります.
- セントジョンズワートは,SSRIと共に軽度のセロトニン症候群を引き起こし,ディゴキシン,セオフィリン,サイクロスポリン,フェンプロキュモンの生物利用性を低下させる可能性があります.
- パナックス・ジンセン (Panax ginseng) は,抗うつ剤を服用している患者でマニアを誘発する可能性があります;ベテルナッツは,神経麻痺薬でエクストラピラミッド効果を悪化させる可能性があります.
- ヨヒンビンは,三環抗うつ剤で高血圧のリスクを増やす可能性があります;甘草はコルチコステロイドを強化します.
- 特定の中国とアーユルヴェーダの薬剤は,特定の薬剤の血中濃度を低下させる可能性があります.
結論:
- ハーブ薬の相互作用は,薬剤の有効性の変化から重度の有害事象まで,重大なリスクを伴います.
- 報告された多くの相互作用には詳細な分析が欠け,慎重に解釈する必要がある.
- 医療従事者は,処方箋または非処方箋の医薬品とハーブ製品を組み合わせる潜在的な危険性について,積極的に患者に助言しなければなりません.
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