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Updated: May 5, 2026

In vivo and in vitro Studies of Adaptor-clathrin Interaction
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In vivo and in vitro Studies of Adaptor-clathrin Interaction

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基礎側PDZタンパク質 Scribbleによって頂上上皮質決定体の局所化

D Bilder1, N Perrimon

  • 1Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. bilder@rascal.med.harvard.edu

Nature
|February 25, 2000
PubMed
まとめ

隔膜交差点に位置するドロソフィラのスクリブル (スクリブ) タンパク質は,上皮細胞の極性を維持するために不可欠です. スクリブ機能の喪失は,アピカルタンパク質の誤局を引き起こし,細胞の形状と組織組織を混乱させます.

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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