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Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Updated: Jul 8, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

なぜ幹細胞なのか?

D van der Kooy1, S Weiss

  • 1Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada. derek.van.der.kooy@utoronto.ca

Science (New York, N.Y.)
|February 26, 2000
PubMed
まとめ

ほとんどの幹細胞は,組織を更新し,長期的な生存を保証するために,発達の遅い段階で発生します. 驚くべきことに,成人の幹細胞は様々な組織を補充することができ,その機能に関する以前の理解に挑戦しています.

科学分野:

  • 発達生物学 発達生物学とは
  • 幹細胞生物学 幹細胞生物学とは
  • 進化生物学の進化生物学について

背景:

  • 幹細胞は,発達と組織維持に不可欠です.
  • その起源と正確な役割,特に成人生物における役割は,現在進行中の研究分野である.
  • 幹細胞の機能を理解することは再生医療の鍵です.

研究 の 目的:

  • 幹細胞の機能的,進化的,発達的な側面を探求する.
  • 生物の発達過程で幹細胞の出現のタイミングを調査する.
  • 組織補充における成人の幹細胞の可能性を調査する.

主な方法:

  • 幹細胞生物学に関する既存の文献のレビュー.
  • 幹細胞の起源に関連する発達および進化データの分析.
  • 大人の幹細胞の可塑性に関する最近の発見の統合.

主要な成果:

  • 幹細胞は,早期ではなく後期に発現することが多い.
  • ほとんどの幹細胞の主な役割は,長期的な生存のために組織再生であるようです.
  • 組織特異的な成人の幹細胞は,複数の成人の組織に寄与する可能性を実証しています.

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Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
07:06

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta

Published on: April 3, 2017

Setting a Successful Sorting for Extracellular Vesicle Isolation
08:37

Setting a Successful Sorting for Extracellular Vesicle Isolation

Published on: October 11, 2024

関連する実験動画

Last Updated: Jul 8, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
07:06

Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta

Published on: April 3, 2017

Setting a Successful Sorting for Extracellular Vesicle Isolation
08:37

Setting a Successful Sorting for Extracellular Vesicle Isolation

Published on: October 11, 2024

結論:

  • 幹細胞のタイミングと機能に関する従来の見解は,再評価を必要としています.
  • 大人の幹細胞の可塑性は,治療的介入のための新しい道を開く.
  • 幹細胞の起源と多組織性の可能性に関するさらなる研究が必要である.