Syncytinは,ヒトの胎盤形質変異に関与するキャプティブレトロウイルスエンベロープタンパク質です
Nature
|February 29, 2000
まとめ
ウイルス遺伝子は宿主哺乳類に統合することができます. ヒト内生レトロウイルスW (HERV-W) 封筒遺伝子であるシンチチンは,細胞融合を媒介することによって胎盤の発達に不可欠です.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 遺伝学 遺伝学とは
- 発達生物学 発達生物学とは
背景:
- 哺乳類のウイルスは,しばしばウイルスの利点のために宿主遺伝子を獲得します.
- 逆のシナリオは,宿主生理学へのウイルス遺伝子の統合は,あまり理解されていません.
研究 の 目的:
- 哺乳類の宿主生理学におけるウイルスの遺伝子,HERV-Wからのシンチチンの役割を調査する.
- シンチチンがヒトの胎盤発育に作用するかどうかを判断する.
主な方法:
- シンチチンをHERV-W.W.の封筒遺伝子として特定しました.
- 胎盤組織におけるシンチチンの発現を調べた.
- 再結合タンパク質と細胞系を用いてシンチチンの細胞融合能力を評価した.
- 抗シンチチン抗血清を用いた融合の抑制をテストした.
主要な成果:
- シンチチンは主に胎盤のシンチチオトロフォブラストで発現します.
- 再結合シンチチンは,様々な細胞タイプで多核細胞 (シンチチア) の形成を誘導する.
- 抗シンチチン抗血清は,ヒトのトロフォブラスティック細胞の融合を阻害する.
結論:
- ウイルスの遺伝子であるシンチチンは,ヒトの胎盤形態変異に不可欠です.
- シンチチンは,胎盤発達の過程で,おそらくシトトロフォブラスト融合を媒介する.
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