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Updated: Jun 19, 2026

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

転写静音化および長寿タンパク質Sir2はNAD依存ヒストン脱酸化酵素である

S Imai1, C M Armstrong, M Kaeberlein

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

Nature
|February 29, 2000
PubMed
まとめ

酵母Sir2はヒストン脱酸化酵素で,ヒストンからアセチル群を除去することで遺伝子を静止させ,寿命を延長します. このNAD依存型脱酸化は,代謝,遺伝子静止,そして老化を結びつける.

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