血の窒素酸塩と窒素酸塩レベルと,ヒトの高血圧における塩分感度の関係に関する研究:塩分摂取による酸化窒素合成の調節
N Fujiwara1, T Osanai, T Kamada
1Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan.
Circulation
|March 1, 2000
まとめ
塩の摂取は高血圧患者の酸化窒素 (NO) レベルに影響します. NO合成の減少とADMAの増加は,ヒトの高血圧における塩分感受性と相関しています.
科学分野:
- 心血管科学の研究について
- 高血圧研究 高血圧研究
- 酸化窒素の代謝について
背景:
- 高塩分摂取は,動物モデルにおける周辺血管における酸化窒素 (NO) の影響を抑制することが知られている.
- ヒトの高血圧における内生的なNO調節と塩分感受性の関係については,さらなる調査が必要である.
研究 の 目的:
- 固有のNO調節がヒトの高血圧における塩分感受性に関連しているという仮説を検証する.
- NO濃度の変化における塩の摂取の役割と,血圧とADMAとの相関を調査する.
主な方法:
- エッセンシャル高血圧患者 (n=24) とノルモテンシブ患者 (n=16) は,食塩操作 (正常,低,高) を受けました.
- 血圧,血酸塩/ナイトライト (NOx) および非対称性ダイメチルアルギニン (ADMA) レベルを測定した.
- 高血圧の患者は,塩の負荷に対する血圧の反応に基づいて,塩に敏感 (1群) と耐塩 (2群) とに分けられた.
主要な成果:
- 血のNOx濃度は,塩に敏感な高血圧患者では,塩に抵抗性および正常血圧のグループと比較して低かった.
- 塩の負荷は,血 NOx を減らし,血 ADMA レベルを上昇させた;塩の制限は,これらの変化を逆転させた.
- 血のNOx濃度の変化は,血圧と血のADMA濃度と,塩の操作後の逆相関関係にある.
結論:
- 食中の塩の摂取は高血圧の個体においてNO合成を調節する.
- ADMAレベルの変化は,ヒトの高血圧における塩分摂取,NO調節,塩分感受性との関連を媒介する可能性がある.
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