交感活動,バロレフレクスの感受性,および若い女性における血管伝導に対する月経周期の影響
C T Minson1, J R Halliwill, T M Young
1Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA. minson.christopher@mayo.edu
Circulation
|March 1, 2000
まとめ
月経周期中のホルモン変化は交感神経の活動に影響するが,それが血管抵抗にどのように影響するかには影響しない. これは,交感性バロレフレクスの感受性に影響します.
科学分野:
- 心血管生理学 心血管の生理学
- 神経内分泌学の神経内分泌学
背景:
- 月経周期には,自律神経系の機能に影響を与えるかもしれないホルモンの変動が含まれています.
- これらの変化を理解することは,循環中の心血管反応の解釈に不可欠です.
研究 の 目的:
- 交感性および心血管性バロレフレクスの感度の変化を調査する.
- 交感神経の活性が,月経周期の各段階で血管抵抗に変換される過程を評価する.
主な方法:
- 筋肉交感神経活動 (MSNA) と血管抵抗は,マイクロニューログラフィとプレチスモグラフィを使用して測定されました.
- 交感性バロレフレクスの感受性は,ナトリウムニトロプルシドとフェニレフリンによって誘発された血圧の変化を介して評価されました.
- 心血管バロレフレクスの敏感度は,R-R区間と静脈動脈血圧の関係によって決定された.
主要な成果:
- 休息中のMSNAとプラズマのノレピネフリン濃度は,早期の卵泡 (EF) 期と比較して,ミドルュテアル (ML) 期において有意に高かった.
- 交感性バロレフレクスの感受性 (MSNA/ダイアストリック血圧の傾き) は,EF相よりもML相において有意に大きかった.
- 段階間の心血管内気反射感度や血管伝導の有意な違いは見つかりませんでした.
結論:
- 月経周期中のホルモンシフトは,交感性流出を調節する.
- 交感性活性が血管抵抗に影響を与える能力は,初期の卵泡とミドルュテアル段階において一貫しています.
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