交感神経放電の振動パターンと,静止刺激中の心血管の変数
1Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale L. Sacco, and Centro LITA di Vialba, Università degli Studi di Milano, Milan, Italy. raffaellof@fisiopat.sacco.unimi.it
Circulation
|March 1, 2000
まとめ
頭を上向きに傾ける時,筋肉交感神経活動 (MSNA) と心拍の変動は,共通の低周波振動パターン (LF) を共有しています. これは,交感活性化中の同期神経交感放電と心血管の調節を示唆しています.
科学分野:
- 心血管生理学 心血管の生理学
- 自律神経系の規制について
- 神経科学は神経科学である.
背景:
- 交感神経系の活動は,心拍数と血圧に影響を与えます.
- ヘッドアップの傾きは,自律的反応を評価するための一般的な操作です.
- 交感活動における振動パターンの理解は,心臓血管の健康にとって極めて重要です.
研究 の 目的:
- 交感性神経活性 (MSNA) と心血管の変動が交感性活性化中に共通の振動パターンを共有しているかどうかを調査する.
- MSNA変動の低周波 (LF) コンポーネントが,ヘッドアップの傾き時の心血管リズムと関連しているかどうかを判断する.
主な方法:
- 10人の健康な被験者に,横横の休息と75度の頭上傾きで心電図,動脈圧,およびMSNAの記録を行いました.
- R-R区間のLF (0.1 Hz) とHF (0.27 Hz) コンポーネント,静脈動脈圧 (SAP) とMSNAを評価するために,スペクトルおよびクロススペクトル解析が使用されました.
- カテコラミン濃度は,休息状態と傾き状態で測定されました.
主要な成果:
- ヘッドアップの傾きは,心拍数,MSNA,およびプラズマカテキオラミンを増加させ,交感性の活性が強化されたことを示しました.
- MSNA変動のLF構成要素 (LF(MSNA)) は,傾き時に増加し,R-R区間のLF構成要素とSAP変動の増加を反映した.
- MSNA,R-R区間,およびSAPのLFコンポーネント間のカップリングは,傾き中に強化されました.
結論:
- 増加したLFリズムによって特徴づけられる一般的な振動パターンは,ヘッドアップの傾きによって誘発された交感活性化中に神経交感放電,心拍数変動,動脈圧変動で現れる.
- これは,生理学的ストレス中に心血管機能の同期された自律的調節を示唆しています.
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