期間限定の冠動脈閉塞の再注射中に,体内の心筋糖代謝の持続的な変化
P H McNulty1, D Jagasia, G W Cline
1Sections of Cardiovascular Medicine, Connecticut VA Medical Center, Yale University School of Medicine, New Haven, CT 06510, USA.
Circulation
|March 1, 2000
まとめ
心臓発作の再注射の後,心臓はエネルギーのためにグルコースの使用を増加させます. これは,麻酔からの回復におけるグルコース代謝の役割を示唆し,過去のイシュケミアを検出する方法を提示する可能性があります.
科学分野:
- 心血管生理学 心血管の生理学
- メタボリック・バイオケミストリー
- 発血性心臓病の研究について
背景:
- 冠動脈閉塞後の再注血は心臓機能を回復しますが,しばしば後発血性麻痺によって遅延されます.
- 麻酔からの回復は完全に理解されていませんが,心臓のグルコース代謝の適応的な変化を伴う可能性があります.
研究 の 目的:
- リバーシブル冠動脈閉塞後の地域グルコース代謝の持続的な変化を vivo で調査する.
- 心筋麻痺からの回復におけるグルコース代謝の役割を調査する.
主な方法:
- ラットで20分間の左冠動脈閉塞を行い,その後24時間の再注血を行った.
- 地域グルコース代謝の評価は, in vivo の [(13) N]NH(3) と [(18) F] のフッ素酸化グルコース (FDG) トレーサーの吸収を用いて行われました.
- 分析されたグリコゲン合成,グリコゲン枯渇,および再流された心筋内におけるグリコリスへのグルコースの流れ.
主要な成果:
- 再循環した領域は正常な収縮性と活性を示したが,24時間後に血流が低下し,グルコースの吸収が増加した.
- これらの領域は,低グリコゲン合成,持続的なグリコゲン枯渇,およびグリコリシスへのグルコースシャントの増加を示した.
- 血液の流れが25%減少し,再注射された領域でグルコースの吸収が50%増加しました.
結論:
- 制限された冠動脈閉塞後の再注射中に地域性グリコリティックグルコース消費量の持続的な増加が発生します.
- in vivo 発作後の麻痺からの回復において,グリコリティックATPの役割を示唆している.
- [(13) N] NH(3) /FDG不一致は,後期地域性心筋不全症の臨床マーカーとして機能する可能性があります.
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