HIV-1疾患の進行に対する最近の胸膜の移住者の影響
A Hatzakis1, G Touloumi, R Karanicolas
1Department of Hygiene and Epidemiology, Athens University Medical School, Greece.
Lancet (London, England)
|March 4, 2000
まとめ
下のT細胞受容体再構成切除DNAサークル (TREC) レベルは,より速いHIV-1疾患の進行を予測します. TRECの測定は,ウイルス負荷とCD4カウントとともに,HIV-1患者の臨床結果を予測するのに役立ちます.
科学分野:
- 免疫学 免疫学とは
- ウイルス学 ウイルス学 ウイルス学
- クリニカル・メディシン 臨床医学
背景:
- 周辺のT細胞におけるT細胞受容体再配置切除DNA円 (TREC) は,最近の胸膜の移住を示している.
- TRECレベルは,免疫再構成と疾患の進行のための潜在的なバイオマーカーとして機能します.
研究 の 目的:
- HIV-1感染者における臨床結果に対するTREC濃度の予測価値を評価する.
- CD4T細胞数,HIV-1RNA負荷などの既知のバイオマーカーと併用してTRECの予後的意義を評価する.
主な方法:
- TREC濃度は,周辺血液単核細胞におけるリアルタイムPCRアッセイを用いて定量化されました.
- 既知のHIV-1血清変換日付を持つマルチセンター血友病コホート研究 (Multicenter Hemophilia Cohort Study) の131人のギリシャ人参加者のコホートを分析した.
- カプラン・マイヤーとコックスの回帰分析を用いて,予後値を評価した.
主要な成果:
- ベースラインより低いTREC値は,エイズに進行した個体と,進行しなかった個体 (p=0.017) に比べて観察されました.
- TREC値の上昇は,ウイルス負荷とCD4カウントに関係なく,エイズの進行 (aHR=1.44) と死亡 (aHR=1.52) の相対的なリスクの高さに関連していた.
- HIV-1 RNA 負荷と CD4 T 細胞数も,疾患の進行と死亡を独立して予測した.
結論:
- 周辺のT細胞プールにおけるTREC濃度は,HIV-1のRNA負荷とCD4のT細胞数を補完し,HIV-1疾患の進行率を予測するのに役立つ.
- TREC値が示すように,最近の胸膜の移住者は,HIV-1疾患の病原化に役割を果たしています.
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