結腸直腸腫瘍における下垂体腫瘍変容遺伝子の発現
A P Heaney1, R Singson, C J McCabe
1Department of Medicine, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, USA.
Lancet (London, England)
|March 7, 2000
まとめ
pituitary-tumor transforming gene (PTTG1) は,大腸直腸腫瘍において高い発現率を有しており,侵襲性に関連しています. PTTG1の増加は侵襲性大腸直腸がんの兆候であり,治療標的として機能する可能性があります.
科学分野:
- 腫瘍学 腫瘍学
- 分子生物学は分子生物学である.
- がん研究 がん研究
背景:
- 基礎線維芽細胞成長因子 (FGF2) は,大腸がんにおける血管新生とミトゲネシスを促進する.
- 下垂体腫瘍変容遺伝子 (PTTG1) は細胞変容を駆動し,FGF2の分泌を調節する.
- PTTG1は通常,正常な組織では表現が不十分であるが,がん細胞では豊富である.
研究 の 目的:
- 結腸直腸腫瘍におけるPTTG1発現と侵襲性の関係を調査する.
- PTTG1を侵襲性大腸がんの潜在的なバイオマーカーとして評価する.
主な方法:
- PTTG1遺伝子およびタンパク質発現は68の結腸直腸腫瘍で定量化されました.
- 発現レベルは,リンパ節転移,腫瘍の血管性,FGF2発現などの侵襲的な特徴と比較した.
- PTTG1発現は,隣接する正常な結腸直腸組織に正常化しました.
主要な成果:
- PTTG1は,正常組織と比較して,分析されたすべての大腸がんおよびポリープで過剰発現しました.
- より高いPTTG1発現は,リンパ節の侵入と有意に相関していた (p=0.007).
- PTTG1濃度の上昇は,より多くの血管性腫瘍 (p=0.04) で観察されました.
結論:
- 結腸直腸腫瘍におけるPTTG1発現の上昇は,侵襲性の増加と関連しています.
- PTTG1は,侵襲性大腸がんを特定するための貴重なバイオマーカーとして役立つ可能性があります.
- PTTG1は,結腸直腸がん治療の新たな治療標的となる可能性がある.
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