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アンジオテンシンIIは,ヒトの心臓線維芽細胞に多重なプロフィブロティック効果を発揮する

H Kawano1, Y S Do, Y Kawano

  • 1Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, University of California at Los Angeles School of Medicine, CA 90024, USA.

Circulation
|March 15, 2000
PubMed
まとめ

アンジオテンシンII (Ang II) は,ヒトの心臓細胞のAT1受容体を活性化し,心臓線維症を促進します. この研究では,Ang IIの役割が,AT ((1) 受容体シグナル伝達を通じて,線維細胞の結合と細胞外マトリックス蓄積を増加させることを明らかにしています.

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