長期にわたる急激な心房ペースによって引き起こされる心房細動は,心房交感内置の異質な変化と関連しています
J V Jayachandran1, H J Sih, W Winkle
1Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Circulation
|March 15, 2000
まとめ
心房細動 (AF) 中の持続的な心拍の上昇は,心房内の交感神経の活動を増加させます. この変異した自律内置は,心房の電気活動の変化と相関する.
科学分野:
- 心臓病学 心臓病学
- 自律神経科学とは
- 電気生理学 電気生理学
背景:
- 心房細動 (AF) は,急激な速度による構造的および電気生理学的変化を伴う.
- 持続したAFが心房の自律内置に与える影響は不明である.
- この研究では,急激な心房回転率と心房自律内置の関係について調査しています.
研究 の 目的:
- 持続的な心房速度の上昇が,心房内の自律的内置を変化させるかどうかを判断する.
- AF中の電気生理学的改造と自律的変化の相関性を探求する.
主な方法:
- 6匹の犬は,持続的なAFを誘発するために,毎分600拍で心房ペースを施した.
- [C-11]ヒドロキシエフェドリン (HED) によるポジトロン放出トモグラフィーは,交感神経末端の密度を評価するために使用されました.
- ノルエピネフリン濃度と心房電気生理学を分析した.
主要な成果:
- ペースドッグは,対照群と比較して,心房組織におけるHED保持とノレピネフリン濃度が大幅に増加した.
- 門の交感性内置は異質で,右門のHED保持がより多かった.
- 動脈動のサイクルの長さは右心房ではより長く,プロプラノロール治療で増加しました.
結論:
- AFの急速な割合は,心房交感内動の異質な増加につながります.
- これらの自律的変化は,AFの明確な電気生理学的効果と関連しています.
関連する概念動画
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