クロノジェニックの一般的な骨髄性原始体であり,すべての骨髄性系統に起因する
K Akashi1, D Traver, T Miyamoto
1Department of Pathology, Stanford University School of Medicine, California 94305, USA. akashi@leland.stanford.edu
Nature
|March 21, 2000
まとめ
研究者らは,血液の発達における初期の原始細胞を特定した. 共通の骨髄状の祖先は,すべての骨髄状の系統に起因し,血液形成における重要な分岐点をマークします.
科学分野:
- 血液学 ヘマトロジ
- 発達生物学 発達生物学について
- 幹細胞生物学 幹細胞生物学
背景:
- 血液形成性幹細胞 (HSC) は,様々な種類の血液細胞に分化し,徐々に自己再生と系統の可能性を失います.
- HSC-derived progenitorsの正確な系統のコミットメントポイントは,主に定義されていないままです.
- 以前の研究で,T細胞,B細胞,NK細胞の共通のリンパ性原始体 (CLP) が特定されました.
研究 の 目的:
- 最も初期の骨髄性祖先集団を特定し,特徴づけること.
- 早期の血液形成における分岐点を線引きするために.
- 精製された祖先集団の初期遺伝子発現プロファイルを提供すること.
主な方法:
- 細胞表面マーカーとフローサイトメトリーを用いた原始細胞の見込みの識別と浄化.
- 浄化された祖先の微分化可能性を評価するための機能的測定法.
- 血液形成に関連する遺伝子の遺伝子発現プロファイリング.
主要な成果:
- クロノジェニックの一般骨髄原体 (CMP) が特定され,浄化されました.
- CMPは,メガカリオサイト/エリトロサイト,グラヌロサイト/マクロファージの祖先を含むすべての骨髄系を発生させます.
- CLPとCMPは,最古のリンパ系と骨髄系の分岐点を表しています.
結論:
- CMP集団は,CLPの補完であり,最も初期の骨髄性祖先を表しています.
- CMPのメガカリオサイト/エリトロサイト,またはグラヌロサイト/マクロファージの系統への分化は,互いを排斥するイベントです.
- この研究は,血液形成における早期の系統のコミットメントを理解するための枠組みを提供します.
関連する概念動画
Hematopoiesis
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Lineage Commitment
Commitment is the process whereby stem cells:
Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Production of Formed Elements
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Most HSCs commit to...
Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...


