LTPとCaMKIIによってAMPA受容体をシナプスに誘導する:GluR1とPDZドメインの相互作用の要件

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Updated: Aug 10, 2026

Imaging pHluorin-tagged Receptor Insertion to the Plasma Membrane in Primary Cultured Mouse Neurons
12:58

Imaging pHluorin-tagged Receptor Insertion to the Plasma Membrane in Primary Cultured Mouse Neurons

Published on: November 20, 2012

Y Hayashi1, S H Shi, J A Esteban

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Science (New York, N.Y.)
|March 24, 2000
PubMed
まとめ

活動に依存したシナプス可塑性は,アルファ-アミノ-3-ヒドロキシ-5-メチル-4-イソクサゾールプロピオネート受容体 (AMPA-Rs) をシナプスに提供することを含む. このプロセスは,CaMKIIリン酸化ではなく,PDZドメインタンパク質と結合するGluR1サブユニットに依存しています.

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