デング熱感染症の神経学的症状
T Solomon1, N M Dung, D W Vaughn
1Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam. tom.solomon@virgin.net
Lancet (London, England)
|April 1, 2000
まとめ
デング熱ウイルスの感染は,流行地域では脳炎を含む中枢神経系 (CNS) 疾患を引き起こす可能性があります. デング熱の早期診断は,典型的なデング熱の兆候がない場合でも,神経学的症状のある患者にとって非常に重要です.
科学分野:
- アルボウイルス学 アルボウイルス学
- 神経学 神経学とは
- 感染症 感染症は感染症です.
背景:
- デング熱は重要なアーボウイルス感染症で,出血性疾患や血管漏れ症候群などの重症形態が知られている.
- 神経疾患を引き起こすデング熱ウイルスの役割は不明である.
研究 の 目的:
- ベトナム南部におけるデング熱ウイルス感染と中枢神経系 (CNS) 感染症の関連性を調査する.
- デング熱に関連する神経疾患の頻度と臨床的症状を決定する.
主な方法:
- ウイルス培養,PCR,血清および脳脊髄液 (CSF) の抗体検出を用いた中枢神経系感染症の疑いのある患者の将来的調査.
- 病院での対照群との比較.
- 孤立したデング熱ウイルス株の系統遺伝分析.
主要な成果:
- デング熱ウイルス感染症は,中枢神経系感染症患者の4.2%で特定され,対照群 (1.4%) よりも著しく高かった.
- 神経学的症状には,意識の低下と発作があり,9人の患者は脳炎を発症した.
- 6人の患者は退院時に神経学的後遺症を経験したが,死亡者はいなかった.
結論:
- デング熱ウイルスは,流行地域における脳炎および脳病の原因として考慮されるべきである.
- 神経学的症状のある患者には,他のデング熱に関連する特徴の存在に関係なく,デング熱の検査が推奨されます.
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