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Updated: Jul 10, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

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抗凝固剤として因子VIIaのペプチドエキゾサイト阻害剤

M S Dennis1, C Eigenbrot, N J Skelton

  • 1Department of Protein Engineering, Genentech, Inc., South San Francisco, California 94080, USA.

Nature
|April 13, 2000
PubMed
まとめ

新しいペプチド抗凝固剤は,組織因子-因子VIIa複合体を標的として血液の凝固を効果的に阻害します. これらのペプチドは,アロステリックメカニズムを通じてX因子の活性化を阻害し,抗凝固剤の開発に新しいアプローチを提供します.

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