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Updated: May 6, 2026

Ferric Chloride-induced Murine Thrombosis Models
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トロンビン-トロンボモジュリン複合体の抗凝固作用の構造的基礎

P Fuentes-Prior1, Y Iwanaga, R Huber

  • 1Max-Planck-Institut für Biochemie, Martinsried, Germany. fuentes@biochem.mpg.de

Nature
|April 13, 2000
PubMed
まとめ

アルファトロンビンと結合するトロンボモジュリン (TME456) は,基質の特異性を変化させることで,血液の凝固を防ぐ. この構造的な洞察は,TME456が,血栓活性部位を変えることなく,抗凝固剤のタンパク質Cの活性化を促進する方法を明らかにします.

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