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Updated: Feb 12, 2026

A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis
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PAR3は,トロンビンによる PAR4活性化のコファクターである.

M Nakanishi-Matsui1, Y W Zheng, D J Sulciner

  • 1Cardiovascular Research Institute and Daiichi Research Center, University of California, San Francisco 94143-0130, USA.

Nature
|April 15, 2000
PubMed
まとめ

トロンビンは,プロテアゼ活性化受容体 (PAR) を介して血小板を活性化します. マウスのPAR3はコファクタとして作用し,トロンビンがPAR4を活性化させ,Gタンパク質結合受容体シグナル伝達のための新しいメカニズムを明らかにします.

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