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Updated: Jul 18, 2026

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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インテグリンLFA-1は,転写共同活性化剤JAB1と相互作用し,AP-1の活性化を調節する

E Bianchi1, S Denti, A Granata

  • 1Scientific Institute San Raffaele-DIBIT, Milano, Italy. bianchi.elisabetta@hsr.it

Nature
|April 15, 2000
PubMed
まとめ

インテグリンLFA-1シグナル伝達は,c-JunコアクティベーターであるJun活性化ドメイン結合タンパク質1 (JAB1) の核局在を制御することによって,遺伝子発現を調節する. この相互作用は転写因子の活性に影響を与え,細胞機能に影響を与えます.

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