中枢神経系は,食物の摂取を制御する
M W Schwartz1, S C Woods, D Porte
1Department of Medicine, Harborview Medical Center and VA Puget Sound Health Care System, University of Washington, Seattle 98104-2499, USA.
Nature
|April 15, 2000
まとめ
ニューロンの回路と,食物摂取のホルモン調節を理解することは,エネルギーホメオスタシスの鍵です. これらの経路の欠陥は肥満につながる可能性があり,潜在的な薬物開発の標的を強調しています.
科学分野:
- 神経科学は神経科学である.
- エンドクリノロジー エンドクリノロジー
- メタボリズムは
背景:
- エネルギーホメオスタシスは,エネルギー摂取とエネルギー消費を時間とともにバランスをとります.
- 視床下部の神経回路とホルモン信号が,食物の摂取を調節する.
- 重要なシグナル伝達分子における突然変異は,ネズミとヒトにおいて重度の肥満を引き起こす.
研究 の 目的:
- 食物摂取制御における個々のホルモンおよびニューロペプチドシグナル伝達経路の役割を定義する.
- これらの経路の欠陥がどのように肥満につながるかを説明する.
- エネルギーホメオスタシスの理解を深めるために.
主な方法:
- 視床下部シグナル伝達経路に関する現在の研究のレビューと合成.
- 食品摂取規制の複雑さを説明するモデルの開発.
- エネルギーホメオスタシスに影響を与える遺伝的および既得の欠陥の分析.
主要な成果:
- 食品摂取の調節に関与する多数のシグナル伝達分子の特定.
- 肥満の予防における下垂体経路の重要な役割の実証.
- 食品摂取のコントロールの複雑で多重な性質の解明.
結論:
- 食物摂取の調節は,複数のホルモンおよび神経ペプチド経路を含む複雑なプロセスです.
- これらの経路の機能障害は,肥満の重要な原因です.
- これらの経路に関するさらなる研究は,肥満治療のための新しい治療目標をもたらす可能性があります.
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