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I-Ag7と自己免疫糖尿病との関連を解読するための構造的枠組み.

A L Corper1, T Stratmann, V Apostolopoulos

  • 1Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|April 25, 2000
PubMed
まとめ

糖尿病の感受性における重要な分子であるI-Ag7の構造は,より広い結合溝を明らかにします. この構造的な違いは,その独特なペプチド偏好を説明し,自己免疫疾患の発症に影響を与えます.

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