地域的な心臓ハイパーインナーヴェーションと心室不律症の関係
J M Cao1, M C Fishbein, J B Han
1Division of Cardiology, University of California Los Angeles School of Medicine, 90027, USA.
Circulation
|April 26, 2000
まとめ
心臓の交感神経密度の増加は,重度の心不全の患者の自発的な心室動脈不律と関連しています. これは,損傷後の神経の異常な再生が突然の心臓死に寄与することを示唆しています.
科学分野:
- 心臓病学 心臓病学
- 神経科学は神経科学である.
- 病理学 パトロジー
背景:
- 交感神経の活動は,心房不律症において役割を果たします.
- 心交感神経の分布とヒトの心室不律症に関する理解は限られている.
研究 の 目的:
- ヒトにおける心交感神経の分布と自発的な心室不律症との関係を調査する.
主な方法:
- 65人の人間の心臓 (移植受容者,解剖,切除された心室組織) を研究した.
- 交感神経の分布と密度を分析するために,免疫細胞化学染色 (S100,神経繊維,チロシンヒドロキシラーゼ,PGP 9.5) を使用しました.
- 関連神経密度,心室動脈不律症の記録された病歴.
主要な成果:
- 交感神経の地域的な増加は,病んだ心筋と心臓の血管の周りに観察されました.
- 病歴で心室不律症 (1Aグループ) の患者は,無 (1Bグループ) の患者と比較して,神経の総数と長さが大幅に増加しました.
- 左心室のエジェクション分子は著しく減少した (0.22+/-0.07).
結論:
- 自発性心房不律症歴と重度の心不全で交感神経密度の増加との間には関連性があります.
- 怪我後の同情神経密度の異常な増加は,心室不律症と突然の心臓死につながる可能性があります.
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