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関連する概念動画

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...

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関連する実験動画

Updated: Jun 30, 2026

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix
08:46

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

基礎線維芽細胞成長因子は,循環する単細胞と血管壁の組織因子の発現を増加させます.

D Corseaux1, T Meurice, I Six

  • 1Laboratoire d'Hématologie, Centre Hospitalier Régional Universitaire and Faculté de Médecine, Lille, France.

Circulation
|April 26, 2000
PubMed
まとめ

基礎線維芽細胞成長因子 (bFGF) は,ウサギの単細胞および血管細胞における組織因子 (TF) の発現を増加させる. この効果は,正常なウサギでは顕著で,高コレステロールのウサギではあまり顕著ではないため,血栓形成のリスクに関するさらなる調査が必要である.

さらに関連する動画

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay
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Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

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Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
09:46

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

関連する実験動画

Last Updated: Jun 30, 2026

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix
08:46

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay
07:21

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Published on: December 26, 2019

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
09:46

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

科学分野:

  • 血管生物学 血管生物学
  • ヘモスタシス ヘモスタシスとは
  • エンドクリノロジー エンドクリノロジー

背景:

  • 基礎線維芽細胞成長因子 (bFGF) は,血管修復と血管新生を促進することが知られている.
  • bFGFは組織因子 (TF) をインビトロで誘導することができ,これは血栓形成の重要なイニシアターです.
  • 血管新生におけるbFGF誘発のTFの役割は,調査に値する.

研究 の 目的:

  • 系統的bFGF投与が単細胞および血管細胞におけるTF発現を誘発するかどうかを調査する.
  • bFGF投与後の正常および高コレステロール血症のウサギのTF発現を比較するために.

主な方法:

  • TF発現は,正常およびコレステロールを摂取したウサギで研究されました.
  • 動物はbFGFを静脈内投与または塩素注射を受けた.
  • 単細胞と大動脈の断面におけるTF発現は,免疫ヒストキミストリーで評価された.

主要な成果:

  • bFGFの投与は,正常および高コレステロール血症のウサギの両方の単細胞TF発現を著しく増加させた.
  • TF発現は,正常なウサギと比較して,高コレステロール血症のウサギでは低かった.
  • bFGFは,正常なウサギの血管壁に強いTF発現を誘導し,高コレステロールウサギの血管壁に弱い発現を誘導した.

結論:

  • 系統的bFGF投与は,循環する単細胞と血管壁におけるTF発現を著しく増加させる.
  • bFGFのTF発現への影響は,高コレステロール症のウサギよりも正常なウサギで顕著です.
  • bFGF誘発のTF発現の臨床的意義は,体内の血栓形成に関するさらなる研究が必要である.