CD1c媒介のT細胞による,Mycobacterium tuberculosis感染症におけるイソプレノイドグリコリピドの認識
D B Moody1, T Ulrichs, W Mühlecker
1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. bmoody@rics.bwh.harvard.edu
Nature
|April 29, 2000
まとめ
研究者らは,CD1c分子によって提示される,イソプレノイドグリコリピドという新しい種類の脂質抗原を発見した. これらの抗原は,Mycobacterium tuberculosisの感染中にT細胞によって認識され,免疫応答の役割を示唆しています.
科学分野:
- 免疫学 免疫学とは
- 分子生物学は分子生物学である.
- グライコバイオロジーは,
背景:
- CD1抗原のプレゼンテーション経路には脂質が含まれていますが,天然の脂質抗原とCD1制限型T細胞の機能は完全に理解されていません.
- イソプレノイドグリコリピドは進化的に保存され,タンパク質のグリコシル化と細胞壁の合成に不可欠です.
研究 の 目的:
- CD1c受限T細胞によって認識される新しい脂質抗原を特定する.
- マイコバクテリア感染に対する反応として,CD1受限型T細胞の役割を調査する.
主な方法:
- T細胞抗原受容体とCD1cの相互作用と脂質抗原の特徴.
- 感染した個体におけるミコバクテリアのグリコリピドに対するT細胞反応の分析.
主要な成果:
- ヘキソシル-1-フォスフォアイソプロニオイドとマノシル-ベータ1-フォスフォドリコールを含む,保存されたイソプレノイドグリコリピドの一族は,CD1cで提示される抗原として識別されました.
- M. tuberculosisに感染した個体からのCD1c制限型T細胞とTリンパ球は,マンノシル-β1-フォスフォドリホールを認識した.
- 反応は素朴な個体には存在せず,適応免疫の役割を示唆した.
結論:
- 感染中にCD1系によって提示される,広く分布する脂質抗原の新種が定義された.
- この発見は,変化したドリホール脂質を持つ老化または変異した細胞を認識するための潜在的な免疫メカニズムを示唆しています.
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