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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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NF-kappaBがp53媒介によるプログラム細胞死における役割

K M Ryan1, M K Ernst, N R Rice

  • 1Regulation of Cell Growth Laboratory, NCI-FCRDC, Frederick, Maryland 21702-1201, USA.

Nature
|April 29, 2000
PubMed
まとめ

腫瘍抑制剤p53は,p53-媒介の細胞死における重要な要因であるNF-kappaBを活性化することによって,アポトーシスを誘発する. ワイルド型p53腫瘍におけるNF-kappaBを阻害すると,治療効果が低下する可能性があります.

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