II型糖尿病は,閉経前期の女性の内皮機能における性差を撤廃する
H O Steinberg1, G Paradisi, J Cronin
1Department of Medicine, Indiana University School of Medicine, and the Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana, USA.
Circulation
|May 3, 2000
まとめ
女性は男性よりも内皮機能が優れているが,これは部分的には,酸化窒素の放出量が高くなっているためだ. 糖尿病は女性におけるこの機能を低下させ,男性と類似させ,潜在的に同様の心血管疾患率を説明します.
科学分野:
- 心血管科学 心血管科学
- エンドクリノロジー エンドクリノロジー
- 生理学 生理学とは
背景:
- 肥満は,男性において女性よりも心臓血管疾患のリスクが高くなります.
- 伝統的な心血管疾患の危険因子は,この性差を完全に説明できない.
- 肥満と糖尿病の影響から独立した内皮機能の違いを調査した.
研究 の 目的:
- 肥満と関係なく,女性が男性よりも強固な内皮機能を持っているかどうかをテストする.
- 糖尿病が,内皮機能におけるこの性差異を無効にするかどうかを判断する.
- 性別に基づく内皮機能の違いにおける酸化窒素の役割を調査する.
主な方法:
- 血管拡張剤 (メタコリン塩化物とナトリウムニトロプルシド) に対する足の血流 (LBF) の反応を,痩せた,肥満,糖尿病の閉経前女性および男性で研究した.
- L-NMMA (酸化窒素合成酵素阻害剤) に対するLBF反応を正常な男女で評価した.
- 年齢とボディマス指数によってマッチした参加者.
主要な成果:
- 痩せた,肥満の女性は,男性よりもメタコリンに対するLBFの増加が著しく高かった.
- 糖尿病の女性と男性は,メタコリンに対するLBF反応が類似しており,性別差が廃止されたことを示しています.
- L-NMMAは,男性よりも女性においてLBFの減少を大きく引き起こし,女性の酸化窒素合成酵素の活性がより高いことを示唆しています.
結論:
- 閉経前の女性は,酸化窒素の放出が増加したため,内皮に依存する血管拡張が優れているが,これは,マクロ血管疾患の発生率が低いことを説明する可能性がある.
- 糖尿病は,閉経前の女性の内皮機能を著しく低下させ,糖尿病の男性に匹敵する機能障害につながる.
- これらの発見は,糖尿病の男性と女性の間で観察された冠動脈疾患と死亡率の類似性を明らかにする可能性があります.
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